Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice
نویسندگان
چکیده
منابع مشابه
15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury
The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the pro-inflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-γ]). To evaluate the significance of 15-PGDH/15-keto-PGE2 cascade in liver inflammation and ti...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2020
ISSN: 1664-042X
DOI: 10.3389/fphys.2020.00138